Just Try and Trust ACC, which is "Smaller but Smarter" than the conventional affinity beads. Let us together " Regear Chromatography & Simplify Purification".

Try and Trust Affinity Convection Chromatography - Small The guy has great wisdom. "Making chromatography efficient again and making purification simple" in cell gene therapy.

The most admirable feature of affinity convection chromatography: the more expensive it is, the better it sells

The higher the end, the more affordable it is: dT, AAV affinity, lentivirus affinity, 1L convection column binding capacity > 2L affinity microspheres (in some areas, even 3~5L microspheres have a dynamic binding capacity).

ExtPURE pricing: 1L affinity convection chromatography = 1.5~2L affinity microspheres

Fewer steps, higher yield:

Take the AAV purification process (500L bioreactor) as an example:

Reduce TFF1: save about 20m2 membrane cassette;

Less affinity dosage : 1.5L affinity convection chromatography = 3L affinity microspheres;

Higher yield: fewer steps, less interception.

Because of its unique large pore design, convective chromatography columns overcome the problem that ultra-large molecules in the CGT field cannot be carried inside the microspheres compared to traditional microsphere packings. Convection chromatography columns can provide more accessible binding sites and higher binding. capacity, and eliminates the influence of diffusion speed, resulting in higher mass transfer efficiency.

ACC: Fast Capturer with high accessible surface binding site. For AAV and saRNA applications, the dynamic binding capacity of the convection column is 1.5~2 times that of the microsphere packing of the same specification, and the superimposed flow rate is 3~5 times Advantages: The processing capacity per unit time is 5 to 10 times that of traditional microsphere packing. The performance of a 250mL convection column is approximately equal to that of 500 mL to 1L traditional packing. The table below shows the performance comparison of a 2,000 L process-scale AAV feed with a titer of 1 × 10^15 cp/L using conventional affinity packing and an affinity convection chromatography column.

AAV purification solves the Oversize system:
1) Less volume, more efficient productivity;
2) No need to concentrate before affinity capture and ion exchange purification, saving membranes Package;
3) Increase the yield by 5~10%

EXTPURE ACC provides mL~1L level GMP chromatography components, and provides micro and small compliant products for nucleic acids and lentiviruses. Start with the end in the mind, especially for mRNA development companies, when applying for IND, they should also consider GMP-compliant production equipment and systems. EXTPURE ACC provides mL~1L level GMP chromatography components, and provides micro and small compliant products for nucleic acids and lentiviruses. Start with the end in the mind, especially for mRNA development companies, when applying for IND, they should also consider GMP-compliant production equipment and systems.